10007939  Prostaglandin E Synthase-1 (microsomal) (human recombinant)

MGST1-L1; mPGE Synthase-1; PIG12; Prostaglandin H/E Isomerase; Membrane-Associated PGES-1

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• See more Enzyme Activity; High Throughput Screening; Western Blot; Enzymes; Proteins; Recombinant Proteins; Cancer; Inflammation; Pain

For active pharmaceutical ingredients (APIs) related to Prostaglandin E Synthase-1 (microsomal) (human recombinant), see Cayman Pharma

Source: recombinant enzyme isolated from a baculovirus overexpression system in Sf21 cells · Mr: ~21 kDa · Prostaglandin E synthases (PGESs) are enzymes that convert cyclooxygenase (COX)-derived PGH2 to PGE2.1 There are three different PGES enzymes with distinct enzymatic properties, modes of expression, cellular and subcellular localizations, and intracellular functions, two of which are membrane-bound enzymes and have been designated as mPGES-1 and mPGES-2. mPGES-1 is a perinuclear protein belonging to the membrane-associated proteins involved in eicosanoid and glutathione metabolism (MAPEG) superfamily.2 It requires glutathione as an essential cofactor for activity. mPGES-1 is up-regulated in response to various proinflammatory stimuli with a concomitant increased expression of COX-2 and is down-regulated by glucocorticoids.3 mPGES-1 gene knockout studies in mice have indicated a role for mPGES-1-generated PGE2 in female reproduction, inflammation, pain, fever, anorexia, atherosclerosis, stroke, and tumorigenesis. Therefore, mPGES-1 is a potential drug target for various diseases.1
1  Friesen, R.W., Mancini, J.A. Microsomal prostaglandin E2 synthase-1 (mPGES-1): A novel anti-inflammatory therapeutic target. J Med Chem 51(14) 4059-4067 (2008).
2  Ouellet, M., Falgueyret, J., Ear, P.H., et al. Purification and characterization of recombinant microsomal prostaglandin E synthase-1. Protein Expr Purif 26 489-495 (2002).
3  Forsberg, L., Leeb, L., Thorén, S., et al. Human glutathione dependent prostaglandin E synthase: Gene structure and regulation. FEBS Lett 471 78-82 (2000).

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Pricing Information

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Size Price Quantity
250 units €124.00
500 units €236.00
1 Kunits €446.00
Pricing updated 2010-08-01.
Prices are subject to change without notice.