10007630  Caspase-8 (human recombinant)

MCH5; MACH; FLICE

• See below for pricing and ordering
• See more Enzyme Activity; Enzymes; Proteins; Apoptosis; Cancer

For active pharmaceutical ingredients (APIs) related to Caspase-8 (human recombinant), see Cayman Pharma

Source: recombinant enzyme expressed in E. coli and purified out of inclusion bodies · Mr: 11 and 19 kDa processed fragments · Caspase-8 is a member of the interleukin-1 converting enzyme (ICE) family of cysteine proteases. It exists in the cell as an inactive 55 kDa proenzyme. During apoptosis, procaspase-8 is processed at aspartate residues by self-proteolysis and/or cleavage by another caspase. The processed form of caspase-8 consists of large and small subunits which associate to form the active enzyme. Caspase-8 activates downstream caspases (caspase 3, 6, and 7) that cleave key cellular substrates and lead to apoptotic cell death.1,2
1  Budihardjo, I., Oliver, H., Lutter, M., et al. Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol 15 269-290 (1999).
2  Goyal, L. Cell death inhibition:Keeping caspases in check. Cell 104 805-808 (2001).

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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

This product is also available to buy in bulk quantities. Please contact us for a quote or to purchase.

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Warning This product is not for human or veterinary use.

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Size Price Quantity
10 µg €159.00
25 µg €377.00
50 µg €713.00
100 µg €1,268.00
Pricing updated 2010-08-01.
Prices are subject to change without notice.