10007599  Prorenin (human recombinant)

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• See more Enzyme Activity; Enzymes; Proteins; Endocrinology; Hypertension; Renal Disease

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Source: recombinant enzyme expressed in HEK cells · Mr: 45 kDa · Prorenin is the inactive precursor of renin, which is a key enzyme in the regulation of blood pressure and electrolyte balance. In renal juxtaglomerular cells, sequential cleavage of the N-terminal 20 and 46 amino acids of preprorenin produces prorenin and active renin, respectively.1 Renin catalyzes the conversion of angiotensinogen to angiotensin I.2 Prorenin exhibits 5-10% of the proteolytic activity of renin, however, the blood circulating levels are 10 times higher.3,4
1  Holzman, T.F., Chung, C.C., Edalji, R., et al. Recombinant human prorenin from CHO cells: Expression and purification. J Protein Chem 9(6) 663-672 (1990).
2  Imai, T., Miyazaki, H., Hirose, S., et al. Cloning and sequence analysis of cDNA for human renin precursor. Proc Natl Acad Sci USA 80 7405-7409 (1983).
3  Sealey, J.E., Atlas, S.A., Laragh, J.H. Prorenin and other large molecular weight forms of renin. Endocr Rev 1(4) 365-391 (1980).
4  Heinrikson, R.L., Hui, J., Zürcher-Neely, H., et al. A structural model to explain the partial catalytic activity of human prorenin. Am J Hypertens 2 367-380 (1989).

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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

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Warning This product is not for human or veterinary use.

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Size Price Quantity
25 µg €252.00
50 µg €479.00
100 µg €908.00
500 µg €3,528.00
Pricing updated 2010-09-09.
Prices are subject to change without notice.