10007417  9-Thiastearic Acid

(CAS 106689-24-1)



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Heteroatom-substituted fatty acids have been observed to modulate the extension and desaturating of fatty acids, and to influence their distribution within phospholipids pools.1,2 9-Thiastearic acid inhibits desaturation of radiolabeled stearate to oleate in rat hepatocytes and hepatoma cells by more than 80% at a concentration of 25 µM.3 This activity is associated with a hypolipidemic effect, making this 9-thiastearic acid a useful tool for evaluating new anti-obesity therapeutics.
1  Wu, P., Grav, H.J., Horn, R., et al. Effects of chain length and sulphur position of thia fatty acids on their incorporation into phospholipids in 7800 C1 hepatoma cells and isolated rat hepatocytes, and their effects on fatty acid composition of phospholipids. Biochem Pharmacol 51 751-758 (1996).
2  Pascal, R.A., Ziering, D.L. Synthesis of heteroatom-substituted analogues of stearic acid. J Lipid Res 27 221-224 (1986).
3  Høvik, K.E., Spydevold, Ø.S., Bremer, J. Thia fatty acids as substrates and inhibitors of stearoyl-CoA desaturase. Biochim Biophys Acta 1349 251-256 (1997).

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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

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Size Price Quantity
5 mg €39.00
10 mg €74.00
50 mg €308.00
100 mg €538.00
Pricing updated 2010-08-01.
Prices are subject to change without notice.