10006749  14,15-Leukotriene C4 EIA Kit (Solid Plate)

14,15-LTC4 EIA Kit; 14,15-Leukotriene C4 ELISA Kit



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• See more EIA (Enzyme Immunoassay); Leukotrienes

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Limit of detection: 80% B/B0: 18 pg/ml · Sensitivity: 50% B/B0: 66 pg/ml · The leukotrienes (LTs) were discovered in 1979 as a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. Although the majority of leukotrienes are formed through the 5-lipoxygenase (5-LO) pathway, a second family of leukotrienes can be formed through an alternate pathway involving the dual actions of 15- and 12-LOs.1,2,3,4 The resulting epoxytriene, 14,15-LTA4, can be converted to 14,15-LTC4, as demonstrated in sheep uterus and RBL-1 cells. Although many of the physiological actions of 14,15-LTC4 remain to be elucidated, it has been shown to have weak contractile activity on both guinea pig ileum and pulmonary parenchyma.5
1  Yokoyama, C., Shinjo, F., Yoshimoto, T., et al. Arachidonate 12-lipoxygenase purified from porcine leukocytes by immunoaffinity chromatography and its reactivity with hydroperoxyeicosatetraenoic acids. J Biol Chem 261 16714-16721 (1986).
2  Bryant, R.W., Schewe, T., Rapoport, S.M., et al. Leukotriene formation by a purified reticulocyte lipoxygenase enzyme. Conversion of arachidonic acid and 15-hydroperoxyeicosatetraenoic acid to 14,15-leukotriene A4. J Biol Chem 260 3548-3555 (1985).
3  Sok, D., Han, C., Shieh, W., et al. Enzymatic formation of 14,15-leukotriene A and C(14)-sulfur-linked peptides. Biochem Biophys Res Commun 104(4) 1363-1370 (1982).
4  Sailesh, S., Kumar, Y.V.K., Prasad, M., et al. Sheep uterus dual lipoxygenase in the synthesis of 14,15-leukotrienes. Arch Biochem Biophys 315(2) 362-368 (1994).
5  Drazen, J.M., Lewis, R.A., Austen, K.F., et al. Contractile activities of structural analogs of leukotrienes C and D: Necessity of a hydrophobic region. Proc Natl Acad Sci USA 78(5) 3195-3198 (1987).

Download Product Insert 706 Kb PDF
Download Abbreviated Kit Protocol 424 Kb PDF
Download Material Safety Data Sheet (MSDS) 227 Kb PDF

Pricing Information

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96 wells €404.00
480 wells €1,512.00
Pricing updated 2010-08-01.
Prices are subject to change without notice.