10006409  Adipose Triglyceride Lipase Polyclonal Antibody

Phospholipase A2ζ; Desnutrin; ATGL



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• See more Immunohistochemistry; Molecular Biology; Western Blot; Antibodies; Fatty Acids; Atherosclerosis; Diabetes; Endocrinology; Metabolism

For active pharmaceutical ingredients (APIs) related to Adipose Triglyceride Lipase Polyclonal Antibody, see Cayman Pharma

Antigen: human adipose triglyceride lipase (ATGL) amino acids 382-400 (KRKLGRHLPSRLPEQVELR) · Host: rabbit · Application(s): WB and IHC (paraffin-embedded sections); other applications not tested · Triglycerides are the most efficient form of energy storage in mammalian adipose tissue during times of caloric excess. ATGL is one of the key enzymes involved in the mobilization of fatty acids from triglyceride stores in adipose tissue, catalyzing the conversion of triacylglycerols to diacylglycerols.1 Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity, and thus may be a potential drug target for the diabetic pathology.1 ATGL mRNA is detected in a wide range of tissues including adipose, lung, skeletal muscle, testis, heart, brain, and kidney, with adipose tissue expressing the highest level.2 Human ATGL is 504 amino acids in length with an estimated molecular weight of 55.2 kDa. Cayman’s ATGL polyclonal antibody detects the enzyme at 56 kDa by western blot from tissues and cells such as brown fat, liver, murine macrophages, and Hep-G2 cells.
1  Zimmermann, R., Strauss, J.G., Haemmerle, G., et al. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 306 1383-1386 (2004).
2  Villena, J.A., Roy, S., Sarkadi-Nagy, E., et al. Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids. Ectopic expression of desnutrin increases triglyceride hydrolysis. J Biol Chem 279(45) 47066-47075 (2004).

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Pricing updated 2010-08-01.
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