10004946  14,15-EE-5(Z)-E

14,15-Epoxyeicosa-5(Z)-enoic Acid (CAS 519038-92-7)



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Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity.1 14,15-EE-5(Z)-E is a structural analog of 14(15)-EET that antagonizes EpETrE-induced relaxation of vascular smooth muscle.2 Relaxation of U46619-constricted bovine arteries by 14,15-EET could be inhibited approximately 80% by 14,15-EE-5(Z)-E at a concentration of 10 µM. 14,15-EE-5(Z)-E does not appear to antagonize nitric oxide- or iloprost-mediated vascular relaxation.
1  Fleming, I. Cytochrome P450 epoxygenases as EDHF synthase(s). Pharmacol Res 49 525-533 (2004).
2  Gauthier, K.M., Deeter, C., Krishna, U.M., et al. 14,15-Epoxyeicosa-5(Z)-enoic acid: A selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries. Circ Res 90 1028-1036 (2002).

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Pricing Information

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Size Price Quantity
25 µg €39.00
50 µg €74.00
100 µg €138.00
500 µg €538.00
Pricing updated 2010-08-01.
Prices are subject to change without notice.