100025  5-OxoETE Receptor Polyclonal Antibody

TG1019; R527

• See below for pricing and ordering
• See more Immunocytochemistry; Immunohistochemistry; Western Blot; Antibodies; Allergy/Asthma; Immunology; Inflammation

For active pharmaceutical ingredients (APIs) related to 5-OxoETE Receptor Polyclonal Antibody, see Cayman Pharma

Antigen: human 5-OxoETE receptor C-terminal amino acids 408-423 · Host: rabbit · Application(s): WB and ICC; other applications not tested · 5-Oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OxoETE) is a potent stimulator of chemotaxis for eosinophils and neutrophils that mediates its action via a putative G-protein coupled receptor (GPCR).1,2 The 5-OxoETE receptor couples to Gi/o to inhibit cyclic AMP production and to mobilize intracellular calcium.1,2 Northern blot analysis reveals that the receptor is highly expressed on eosinophils and neutrophils, suggesting a key role in the inflammatory response.2 In addition, the protein can also be detected in tissues such as kidney and liver.1,2 Cayman Chemical’s 5-OxoETE receptor polyclonal antibody can be used in western blot analysis (detection at 48 kDa) and immunocytochemistry. The high expression level of the receptor in leukocytes makes it the best positive control sample. When probing other tissue samples such as liver and kidney, membrane preparations or higher sensitivity detection systems may be required for visualization on immunoblot.
1  Hosoi, T., Koguchi, Y., Sugikawa, E., et al. Identification of a novel human eicosanoid receptor coupled to Gi/o. J Biol Chem 277 (35) 31459-31465 (2002).
2  Jones, C.E., Holden, S., Tenaillon, L., et al. Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils. Mol Pharmacol 63(3) 471-477 (2003).

Download Product Insert 99 Kb PDF
Download Material Safety Data Sheet (MSDS) 23 Kb PDF

Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

This product is also available to buy in bulk quantities. Please contact us for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Item total €0.00
Shopping cart total €0.00
Size Price Quantity
1 ea €270.00
Pricing updated 2010-08-01.
Prices are subject to change without notice.