| Intro | Product | Cat No | Image |
|---|---|---|---|
| 24.05.13 |
An inhibitor of TPPII
AAF-
|
14461 |
|
| 24.05.13 |
A selective inhibitor of PDGF receptor kinase
AG-
|
14529 |
|
| 24.05.13 |
A reversible channel blocker of TRPA1
AP-
|
11912 |
|
| 24.05.13 |
A potent, selective PAF receptor antagonist
Apafant is a water soluble, selective platelet-
|
14532 |
|
| 23.05.13 |
A colorimetric caspase substrate
Ac-
|
14460 |
|
| 23.05.13 |
An essential energy substrate for cellular metabolism
Adenosine 5'-
|
14498 |
|
| 23.05.13 |
A nucleoside analog that inhibits polyadenylation
Cordycepin is a nucleoside analog found in C. sinensis that acts as a polyadenylation inhibitor when converted to 3'-
|
14426 |
|
| 23.05.13 |
A fluorescent probe for direct detection of ONOO-
Coumarin boronic acid (CBA) is a fluorescent probe that reacts directly and rapidly with ONOO-
|
14051 |
|
| 23.05.13 |
A muscarinic receptor antagonist
Darifenacin is a receptor antagonist acting at the muscarinic receptors (Ki = 5.5, 47, 0.84, 8.6, and 2.3 nM for M1 through M5, respectively). It is effective in treating problems related to the lower urinary tract, including incontinence and overactive bladder.
|
14424 |
|
| 23.05.13 |
An antibiotic used in inducible gene expression systems
Doxycycline hyclate is a tetracycline-
|
14422 |
|
| 23.05.13 |
A pyrimadine analog that inhibits DNA synthesis
Fluorouracil is a pyrimadine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. Intracellular metabolites of fluorouracil exert cytotoxic effects by either inhibiting thymidylate synthetase, or through incorporation into RNA and DNA, ultimately initiating apoptosis. Fluorouracil has been widely used to treat many gastrointestinal tract adenocarcinomas. However, its clinical application is greatly limited due to drug resistance.
|
14416 |
|
| 23.05.13 |
An indoleamine neurohormone that entrains circadian rhythms
Melatonin is an indoleamine neurohormone whose levels vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions in animals, plants, and microbes. Many biological effects of melatonin are transduced through melatonin receptors, including the MT1, MT2, and MT3 subtypes. Melatonin also acts as a powerful antioxidant that protects lipids, proteins, and DNA against oxidative damage. Glutathione peroxidase, superoxide dismutases, and catalase are upregulated by melatonin, and melatonin scavenges free radicals as a terminal antioxidant.
|
14427 |
|
| 22.05.13 |
Source:
Recombinant N-
|
14490 |
|
| 22.05.13 |
A fluorescent probe for detection of hydrogen peroxide
The pinacolate ester of coumarin boronic acid (CBA) reacts with hydrogen peroxide to form the highly fluorescent 7-
|
10818 |
|
| 22.05.13 |
A lipid staining dye
Oil Red O is used to stain lipids, neutral triglycerides, and some lipoproteins, particularly in cells in culture or in tissues. It is commonly used to evaluate adipogenesis in vitro, as it stains lipid droplets in adipocytes. Oil Red O also positively stains lipid-
|
14419 |
|
| 21.05.13 |
A PKA activator
8-
|
14431 |
|
| 21.05.13 |
A cell-
8-
|
12011 |
|
| 21.05.13 |
An irreversible inhibitor γ-
Buthionine sulfoximine (BSO) is an irreversible inhibitor γ-
|
14484 |
|
| 21.05.13 |
An excitatory neurotransmitter
NMDA is a synthetic amino acid derivative that acts as a specific agonist at the NMDA receptor, mimicking the excitatory action of the endogenous ligand glutamate. Signaling through the NMDA receptor influences both neuronal plasticity and neurotoxicity. Repetitive activation of NMDA synapses leads to long-
|
14581 |
|
| 20.05.13 |
An antagonist of the nucleotide receptor P2X7
A-
|
14580 |
|
| 20.05.13 |
A racemic mixture of buproprion metabolites
Hydroxy bupropion is a mixture of enantiomers produced by the metabolism of buproprion by cytochrome P450 2B6. Compared with buproprion, this racemic mixture produces equal inhibition of norepinephrine reuptake (IC50 = 1.7 µM) and much weaker inhibition of dopamine reuptake (IC50 > 10 µM). Moreover, hydroxyl bupropion isomers are potent antagonists of nicotinic receptors, suggesting that they may substitute for bupropion in smoking cessation.
|
9000522 |
|
| 20.05.13 |
A fluorescent probe for dsRNA
Pyronin Y is a fluorescent probe which stains double stranded RNA in living or fixed cells as well as in tissues. When used in living cell preparations, it is commonly combined with 50-
|
14488 |
|
| 17.05.13 |
An SSRI used to treat depression
Fluoxetine is a selective serotonin reuptake inhibitor, displaying a marked preference for the serotonin tranporter (Kd = 0.81 nM) over the norepinephrine transporter (Kd = 240 nM) and the dopamine transporter (Kd = 3600 nM). It is effective in the clinical treatment of major depression as well as other psychiatric disorders.
|
14418 |
|
| 17.05.13 |
Antitumor antibiotic used in treatment of leukemia
Idarubicin is a 4-
|
14176 |
|
| 17.05.13 |
A broad-
Minocycline is a broad-
|
14454 |
|
| 17.05.13 |
A natural inhibitor of various transporters
Phloretin is a natural phenol which inhibits a variety of transporters. It inhibits the monocarboxylate transporters MCT1 and MCT2 (IC50 = 28 and 14 µM, respectively), restricting the rapid transport of monocarboxylates like lactate and pyruvate across the plasma membrane. Phloretin also blocks the sodium/D-
|
14452 |
|
| 17.05.13 |
An inhibitor of CK2
TBB is an ATP/GTP-
|
14453 |
|
| 17.05.13 |
A DAF-
Δ4-
|
14100 |
|
| 15.05.13 |
An inhibitor of anandamide uptake
LY2183240 2’-
|
14523 |
|
| 15.05.13 |
A small molecule activator of PGC-
ZLN005 is a small molecule that stimulates the expression of PGC-
|
14121 |
|
| 14.05.13 |
A potent inhibitor of anandamide uptake
LY2183240 is a potent, competitive small molecule inhibitor of anandamide uptake (IC50 = 270 pM; Ki = 540 pM) and hydrolysis. It has been shown to increase anandamide levels in rat cerebellum (ED50 = 1.37 mg/kg) and displays dose-
|
10008663 |
|
| 14.05.13 |
A potent, NR2B-
Ro 25-
|
14578 |
|
| 14.05.13 |
An inhibitor of cysteine proteases, including cathepsin B
Z-
|
14462 |
|
| 14.05.13 |
A cell-
Z-
|
14463 |
|
| 13.05.13 |
A fluorogenic caspase subsrate
Ac-
|
14459 |
|
| 13.05.13 |
An inhibitor of caspase-
Ac-
|
14465 |
|
| 13.05.13 |
An isatin sulfonamide-
Caspase-
|
14464 |
|
| 13.05.13 |
A potassium channel activator
Diazoxide is a potassium channel activator that causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. The cellular release of potassium switches off voltage-
|
14576 |
|
| 13.05.13 |
Enzyme immunometric assay for the measurement of mouse IL-
Interleukin-
|
500970 |
|
| 13.05.13 |
A selective inhibitor of cyclin-
Purvalanol A is a potent, cell-
|
14579 |
|
| 13.05.13 |
An inhibitor of glutamatergic transmission
Riluzole is a benzothiazole derivative with anti-
|
14577 |
|
| 13.05.13 |
Cell-
SIRT1/2 Inhibitor IV is a cell-
|
14407 |
|
| 09.05.13 |
An inhibitor of pCAF
CAY10669 is an inhibitor of the histone acetyltransferase pCAF (p300/CREB-
|
10974 |
|
| 09.05.13 |
A broad-
Chloramphenicol is a broad-
|
14334 |
|
| 09.05.13 |
A fluoroquinolone antibiotic with antimicrobial and immunomodulatory effects
Ciprofloxacin is a fluoroquinolone antibiotic that is widely used as an antimicrobial and immunomodulatory agent. Its range of activity includes most strains of bacterial pathogens capable of inducing respiratory, urinary tract, gastrointestinal, and abdominal infections. It functions by inhibiting DNA gyrase (a type II topoisomerase) and topoisomerase IV, the enzymes responsible for negative supercoiling of chromosomes and DNA strand separation, thus blocking initiation of bacterial replication. Most recently ciprofloxacin has been used in the management of postexposure inhalational anthrax and radiation combined injury resulting from nuclear disasters.{22832;22834}
|
14286 |
|
| 09.05.13 |
A CB2 receptor agonist
Magnolol is a bioactive compound isolated from the bark of M. officinalis that has been used in Asian traditional medicine for the treatment of anxiety, sleeping disorders, and allergic diseases. Magnolol can activate cannabinoid (CB) receptors, behaving as a partial agonist with selectivity for the peripheral CB2 subtype (EC50 = 3.28 μM; Ki = 1.44 μM) versus central CB1 (EC50 = 18.3 μM; Ki = 3.15 μM).
|
14233 |
|
| 09.05.13 |
A highly selective MAPKAPK2 (MK2) inhibitor
MK 25 is a highly selective, non-
|
14399 |
|
| 09.05.13 |
A protein stain
Ponceau S is a stain that permits the rapid, reversible detection of proteins immobilized on various matrices, including nitrocellulose and polyvinylidene fluoride membranes. It can be used to locate proteins or evaluate efficiency of transfer. Reversible staining with ponceau S has also been validated as an alternative to actin probing as a loading control. This stain can also be used as a fiducial marker in mass spectrometric imaging.
|
14330 |
|
| 09.05.13 |
A CB2 receptor agonist
Tetrahydromagnolol is a major metabolite of magnolol that is 19-
|
14234 |
|
| 08.05.13 |
A potassium-
Amiloride is a potassium-
|
14409 |
|
| 08.05.13 |
A skeletal muscle relaxant that binds type 1 ryanodine receptors
Dantrolene is a skeletal muscle relaxant that depresses excitation-
|
14326 |
|
| 08.05.13 |
A potent non-
Efavirenz is an NNRTI that prevents RNA plus-
|
14412 |
|
| 08.05.13 |
A selective Group III metabotropic glutamate receptor agonist
L-
|
14538 |
|
| 08.05.13 |
A potent, highly selective mGlu5a receptor antagonist
MPEP is a potent, highly selective non-
|
14536 |
|
| 08.05.13 |
A non-
PPADS is a non-
|
14537 |
|
| 08.05.13 |
A dye used as an oxidation-
Resazurin is a blue non-
|
14322 |
|
| 08.05.13 |
A selective antibiotic used in cell culture systems
Tetracycline is a broad-
|
14328 |
|
| 07.05.13 |
High Throughput Screening assay for BRD2 inhibitors
Bromodomains recognize acetylated lysine residues and recruit regulatory complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. The isolated individual or tandem bromodomains of BRD2 and BRD4 bind acetylated histone tails, which couple histone acetylation marks to the transcriptional regulation of target promoters. Small molecule inhibitors of bromodomain/histone interactions hold promise as useful therapeutics for human disease. Cayman’s BRD2 bromodomains 1 and 2 TR-
|
600810 |
|
| 07.05.13 |
A vital dye with multiple utility
Bromophenol blue is commonly used as a pH indicator, a color marker to monitor the progress of agarose or polyacrylamide gel electrophoresis, and a dye to detect proteins and nucleic acids (absorbance at 610 nm), particularly when staining living tissues. As an acid-
|
14331 |
|
| 07.05.13 |
High Throughput Screening assay for CBP inhibitors
CBP (CREB-
|
600850 |
|
| 07.05.13 |
A selective NMDA antagonist
D-
|
14539 |
|
| 07.05.13 |
A competitive NMDA antagonist
DL-
|
14540 |
|
| 07.05.13 |
A nonspecific, irreversible serine protease inhibitor
Phenylmethylsulfonyl fluoride (PMSF) is a nonspecific, irreversible inhibitor of serine proteases and other enzymes, including acetylcholinesterase, palmityl coenzyme A deacylase, arylsulfatase A, chymotrypsin, and trypsin. It is used in protein solublization studies in order to deactivate proteases from digesting proteins of interest after cell lysis. Because PMSF specifically sulfonylates the hydroxal groups of active site serine residues of enzymes, it can be used as a chemical label to identify essential active site serines in an enzyme. PMSF is known to alter the actions of anandamide by blocking its metabolism and can produce cannabinoid effects in mice, including antinociception, hypothermia, and immobility with ED50 values of 86, 224, and 206 mg/kg, respectively.
|
14333 |
|
| 07.05.13 |
A tryptophan-
Serotonin is a monoamine neurotransmitter that is biochemically derived from tryptophan and produced in serotonergic neurons in the central nervous system and in enterochromaffin cells in the gastrointestinal tract. Serotonin is important in the regulation of mood, sleep, vomiting, sexuality, and appetite. Low levels of serotonin are associated with several disorders, including depression, migraines, bipolar disorder, and anxiety. Its actions are terminated primarily via uptake of serotonin from the synapse. Serotonin reuptake can be inhibited with MDMA, cocaine, tricyclic antidepressants, and selective serotonin reuptake inhibitors.
|
14332 |
|
| 06.05.13 |
A fluorescent cationic dye useful for cell cycle determination
Acridine orange is a cell permeable, nucleic acid-
|
14338 |
|
| 06.05.13 |
An antibacterial antibiotic
Ampicillin is an antibacterial antibiotic from the α-
|
14417 |
|
| 06.05.13 |
A neuroprotective hybrid of curcumin
J 147, a hybrid of curcumin (Item No. 81025) and the neurotrophic compound, cyclohexyl-
|
14451 |
|
| 06.05.13 |
The trans isomer of palmitoleic acid
Palmitelaidic acid is the trans isomer of the 16:1 fatty acid palmitoleic acid. While its effects on cholesterol levels are poorly studied, palmitelaidic acid can have very different effects from those of palmitoleic acid on lipid metabolism and mobilization.
|
9001798 |
|
| 06.05.13 |
The trans isomer of palmitoleic acid
Palmitelaidic acid methyl ester is an ester version of the free acid which may be more amenable for the formulation of fatty acid-
|
9001797 |
|
| 06.05.13 |
Source:
recombinant N-
|
14495 |
|
| 03.05.13 |
An irreversible serine protease inhibitor
AEBSF is a water soluble, irreversible, broad spectrum inhibitor of serine proteases, including trypsin, chymotrypsin, plasmin, thrombin, and kallikreins. AEBSF can also prevent the activation of the ROS generator, NADPH oxidase. At 10-
|
14321 |
|
| 03.05.13 |
A dye for staining or quantifying proteins
Brilliant Blue G is a dye which is commonly used in laboratories to stain or quantify proteins. A variety of methods have been developed for using Brilliant Blue G to stain gels with ease and sensitivity. The Bradford assay is a standard, rapid dye-
|
14320 |
|
| 03.05.13 |
A sodium-
Dapagliflozin is a first generation, selective sodium-
|
11574 |
|
| 03.05.13 |
A fluorescent DNA probe
DAPI is a fluorescent probe which is commonly used to stain DNA and chromosomes for fluorescent microscopy and flow cytometry applications. It forms a fluorescent complex by attaching in the minor groove of A-
|
14285 |
|
| 03.05.13 |
An antagonist of histamine and muscarinic receptors
Diphenhydramine (DPH) is a first generation antihistamine which is a potent antagonist of the human H1 receptor (Ki = 11.7 nM). Like many first generation antihistamines, DPH readily crosses the blood-
|
11158 |
|
| 03.05.13 |
A dye used to stain proteins for IEF and SDS-
Fast Green FCF is a dye used to stain proteins for IEF (isoelectric focusing) and SDS-
|
14335 |
|
| 03.05.13 |
A fluoroquinolone antibiotic
Gatifloxacin is a fluoroquinolone antibiotic which inhibits bacterial DNA gyrase (IC50 = 0.109 μg/ml) and topoisomerase IV (IC50 = 13.8 μg/ml). It is much less effective against HeLa cell topoisomerase II (IC50 = 265 μg/ml). Gatifloxin has been used as a broad-
|
14290 |
|
| 02.05.13 |
A potent inducer of chondrocyte differentiation
Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes with an EC50 value of 100 nM. Kartogenin induces chondrogenesis by binding the actin-
|
11826 |
|
| 02.05.13 |
An antagonist of muscarinic receptors
Tolterodine tartrate is a competitive antagonist of muscarinic (M) receptors (Ki = 1.4, 2.7, 3.6, 3.1, and 2.2 nM for M1 through M5, respectively). Antagonists of muscarinic receptors, including tolterodine, are effective in treating overactive bladder symptoms.
|
15027 |
|
| 02.05.13 |
A partial agonist of the α4β2 nicotinic receptor
Varenicline tartrate is a partial agonist of the α4β2 neuronal nicotinic acetylcholine receptor (EC50 = 2.3 µM). It shows high selectivity for this receptor subclass relative to other nicotinic receptors, non-
|
15030 |
|
| 01.05.13 |
A macrolide antibiotic
Azithromycin is a macrolide antibiotic with high stability at acidic pH, long half-
|
15004 |
|
| 01.05.13 |
A major isoflavone
Glycitein is an O-
|
14162 |
|
| 01.05.13 |
A specific inhibitor of mTOR activity
Temsirolimus is a dihydroxymethyl propionic acid ester of rapamycin with improved solubility that specifically inhibits mTOR signaling with a potency similar to that of rapamycin. Treatment with temsirolimus leads to cell cycle arrest in the G1 phase and also inhibition of tumor angiogenesis by reducing synthesis of VEGF. Temsirolimus demonstrates cytostatic activity in several xenograft models of human tumors in nude mice, including glioblastomas, prostate carcinoma, pancreatic, liver, and breast cancers, and medulloblastoma.
|
11590 |
|
| 01.05.13 |
Inhibitor of caspase-
Z-
|
14414 |
|
| 29.04.13 |
A selective inhibitor of Na+/H+ exchangers
5-
|
14406 |
|
| 29.04.13 |
A selective inhibitor of de novo pyrimidine synthesis
A-
|
14404 |
|
| 29.04.13 |
A peripherally acting, selective and reversible COMT inhibitor
Entacapone is a peripherally acting, selective and reversible COMT inhibitor with IC50 values of 150-
|
14153 |
|
| 29.04.13 |
A cell permeable, selective calpain inhibitor
MDL 28170 is a cell permeable, selective inhibitor of μ-
|
14283 |
|
| 29.04.13 |
An anti-
β-
|
15021 |
|
| 26.04.13 |
A potent and selective agonist of GPR183
7α,25-
|
11032 |
|
| 26.04.13 |
An internal standard for the quantification of RvD2
RvD2-
|
11184 |
|
| 25.04.13 |
An inhibitor of GLI transcription
GANT 58 is a GLI antagonist that inhibits GLI1-
|
14193 |
|
| 25.04.13 |
An antibiotic used to select transformed cells
Hygromycin B is an antibiotic which is used in molecular and cell biology to select for transformed cells expressing the hygromycin resistance gene. It is an aminoglycoside produced by the bacterium S. hygroscopicus which kills prokaryotic and eukaryotic cells by inhibiting protein synthesis. The hygromycin resistance gene (hyg or hph) encodes a phosphotransferase which inhibits hygromycin through phosphorylation.
|
14291 |
|
| 24.04.13 |
An alkylating agent used to treat cancer
Cyclophosphamide is a nitrogen mustard alkylating agent used in the treatment of cancers and autoimmune disorders. In cells with low levels of aldehyde dehydrogenase, cyclophosphamide acts as a prodrug since it is metabolized to the active compound phosphoramide mustard, which crosslinks with DNA and causes cell death.
|
13849 |
|
| 24.04.13 |
An antibiotic used in tissue culture studies
Neomycin is an aminoglycoside antibiotic produced by S. fradiae that inhibits protein translation by binding to the small subunit of prokaryotic ribosomes. It blocks voltage-
|
14287 |
|
| 24.04.13 |
A fluorescent probe used to identify dead cells
Propidium iodide (PI) is membrane impermeant and generally excluded from viable cells. However, it can easily penetrate dead or damaged cells and as such is commonly used for identifying cell viability in a population or as a counterstain in multicolor fluorescent techniques. It binds to DNA and RNA by intercalating between the bases. PI is excited at 488-
|
14289 |
|
| 24.04.13 |
An aminocyclitol antibiotic
Spectinomycin is an aminocyclitol antibiotic produced by S. spectabilis that is active against Gram-
|
14324 |
|
| 24.04.13 |
A potent calmodulin antagonist
W-
|
14277 |
|
| 23.04.13 |
A widely used inhibitor of glycolysis
2-
|
14325 |
|
| 23.04.13 |
A JAK inhibitor
CP 690,550 is a potent, cell-
|
11598 |
|
| 23.04.13 |
A natural isoflavone
Genistin is a natural isoflavone isolated from legumes, including soy and kudzu. It is a phytoestrogen, as it stimulates the growth of estrogen-
|
14174 |
|
| 23.04.13 |
K+ channel inhibitor which stimulates insulin secretion
Glyburide is a sulfonylurea compound which acts as an inhibitor of ATP-
|
15009 |
|
| 23.04.13 |
A natural isoflavone
Glycitin is a natural isoflavone isolated from legumes, including soy and kudzu. Like other isoflavones, glycitin promotes the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover.
|
14161 |
|
| 23.04.13 |
A potent inhibitor of DNA topoisomerase I
Irinotecan, a derivative of the alkaloid camptothecin (Item No. 11694), functions as a prodrug that is converted by tissue carboxylesterase to 7-
|
14180 |
|
| 23.04.13 |
A dual inhibitor of CB1 and FAAH
Isopropyl dodec-
|
11613 |
|
| 23.04.13 |
A synthetic glucocorticoid
Methylprednisolone is a 6α-
|
15013 |
|
| 23.04.13 |
A glycylcycline antibiotic
Tigecycline is a glycylcycline antibiotic that binds to the bacterial 30S ribosome, blocking the entry of transfer RNA, which halts protein synthesis and thus limits bacterial growth. It has a broad spectrum of activity against many Gram-
|
15026 |
|
| 23.04.13 |
A potent inhibitor of DNA topoisomerase I
Topotecan is a water soluble analog of the alkaloid camptothecin that potently inhibits DNA topoisomerase I. It induces cytoxicity and DNA damage in human HT-
|
14129 |
|
| 18.04.13 |
An anthracycline antitumor antibiotic
Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-
|
15007 |
|
| 18.04.13 |
An antibiotic active against Gram-
Linezolid is a synthetic oxazolidinone antibiotic active against a wide range of Gram-
|
15012 |
|
| 18.04.13 |
A potent, selective DP2 antagonist
OC000459 is a potent, selective DP2 antagonist that displaces [3H]prostaglandin D2 ([3H]PGD2) from human recombinant DP2 receptors (Ki = 13 nM), rat recombinant DP2 receptors (Ki = 3 nM), and human native DP2 (Ki = 4 nM; Th2 cell membranes) without interfering with the ligand binding properties of other prostanoid receptors, including PGE1–4, DP1, TP, PGI2, and PGF. OC000459 inhibits chemotaxis and cytokine production of human Th2 lymphocytes with IC50 values of 28 and 19 nM, respectively, and competitively antagonizes eosinophil shape change responses induced by PGD2 in both isolated human leukocytes (pKB = 7.9) and human whole blood (pKB = 7.5). OC000459 was shown to inhibit blood eosinophilia in rats induced by 13,14-
|
12027 |
|
| 18.04.13 |
An antagonist of Smoothened
PF-
|
15022 |
|
| 17.04.13 |
A selective estrogen receptor modulator
Bazedoxifene acetate is a third generation selective estrogen receptor modulator (SERM). It is an indole-
|
15005 |
|
| 17.04.13 |
A specific, cell-
PF-
|
15018 |
|
| 17.04.13 |
A potent, selective inhibitor of CYP3A4
PF-
|
15019 |
|
| 17.04.13 |
An α1-
Prazosin is an antihypertensive agent that blocks postsynaptic α1-
|
15023 |
|
| 17.04.13 |
A prodrug of 5-
Sulfasalazine is a prodrug of the anti-
|
15025 |
|
| 17.04.13 |
A combined serotonin and dopamine receptor antagonist
Ziprasidone is the hydrochloride salt of a benzisothiazolylpiperazine analog structurally related to the atypical antipsychotic drug tiospirone that antagonizes both central serotonin 5-
|
15031 |
|
| 16.04.13 |
An inhibitor of poly(ADP-
DPQ is a potent inhibitor of PARPs, inhibiting PARP-
|
14450 |
|
| 16.04.13 |
An inhibitor of α-
Miglitol is a pseudo-
|
15014 |
|
| 16.04.13 |
An orally active, potent, selective EP2 receptor antagonist
PF-
|
15016 |
|
| 16.04.13 |
An inhibitor of poly (ADP-
PJ-
|
14440 |
|
| 15.04.13 |
A potent inhibitor of Src and Abl kinases
Bosutinib is best known as a potent dual inhibitor of c-
|
12030 |
|
| 15.04.13 |
A binder and modulator of F-
Jasplakinolide is a natural macrocyclic peptide first isolated from a marine sponge. It potently inhibits the proliferation of PC3 prostate carcinoma cells (IC50 = 35 nM) by binding F-
|
11705 |
|
| 15.04.13 |
A potent inhibitor of phosphatase
β-
|
14405 |
|
| 12.04.13 |
An endogenous biogenic amine
(±)-
|
14279 |
|
| 12.04.13 |
A fungal secondary metabolite
Pseurotin A is a secondary metabolite produced by Aspergillus and other fungi. Its expression is induced in response to hypoxia. Pseurotin A has been shown to inhibit IgE production by mouse B cells in culture (IC50 = 3.6 μM) and dose-
|
14441 |
|
| 12.04.13 |
A polycationic dye that blocks Ca2+ release
Ruthenium red is a polycationic dye that inhibits sarcoplasmic reticulum Ca2+ release, blocks Ca2+ uptake and release from mitochondria, and prevents Ca2+ release from ryanodine-
|
14339 |
|
| 11.04.13 |
An inhibitor of poly(ADP-
1,5-
|
14438 |
|
| 11.04.13 |
A PTEN inhibitor
bpV(HOpic) is a bisperoxovanadium (bpV) compound that inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 14 nM). It also inhibits the vascular endothelial PTP, PTP-
|
14433 |
|
| 11.04.13 |
A PTEN inhibitor
bpV(pic) is a bisperoxovanadium (bpV) compound that inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 31 nM). It also inhibits the vascular endothelial PTP, PTP-
|
14434 |
|
| 11.04.13 |
An inhibitor of HIF signaling
Chetomin is a natural product isolated from Chaetomium species which has antibacterial and antifungal properties. It is a small molecule inhibitor of hypoxia-
|
14437 |
|
| 11.04.13 |
A nucleoside analog used in the treatment of leukemia
Clofarabine is a nucleoside analog that inhibits ribonucleotide reductase and DNA polymerase-
|
14125 |
|
| 11.04.13 |
A nucleoside analog used in the treatment of leukemia
Fludarabine is an adenosine deaminase resistant analog of 9-
|
14128 |
|
| 11.04.13 |
A phosphodiesterase inhibitor
Obscurolide A1 is a natural butyrolactone isolated from S. viridochromogenes. It inhibits calcium/calmodulin-
|
14439 |
|
| 10.04.13 |
An antibiotic with nematicidal, insecticidal, antibacterial, and antifungal activity
Asperlactone is a nematicidal, insecticidal, antibacterial, and antifungal polyketide metabolite produced from A. westerdijkiae.
|
14435 |
|
| 10.04.13 |
An anti-
Borrelidin is a secondary metabolite produced by Streptomyces and other bacteria. It displays potent anti-
|
14436 |
|
| 10.04.13 |
Antitumor antibiotic used in the treatment of acute myeloid leukemias
Daunorubicin is an antitumor antibiotic widely used in the treatment of acute myeloid leukemias (AMLs). At 0.2-
|
14159 |
|
| 10.04.13 |
Enzyme immunometric assay for the measurement of mouse IL-
Limit of detection:
15.6 pg/ml
·
Interleukin-
|
500880 |
|
| 08.04.13 |
For the detection of ALDH activity in tissue homogenates, cell culture samples, and purified ALDH preparations
Limit of detection:
0.4 U/ml (±0.1 U/ml) ALDH
·
Aldehyde dehydrogenases (ALDHs) represent a group of enzymes that oxidize a wide range of endogenous and exogenous aldehydes to their corresponding carboxylic acids, which affect both developmental and toxicological functions. Pharmacological inhibitors or activators of ALDH activity have been developed to examine the metabolism of alcohol as well as a number of pathological conditions, including cancer, Type II hyperprolinemia, Sjögren-
|
700800 |
|
| 08.04.13 |
An antibiotic of the lincosamide class
Clindamycin is an antibiotic in the lincosamide class which binds the bacterial 50S ribosomal subunit and interferes with protein synthesis. Evidence suggests that clindamycin is particularly effective against anaerobes and is commonly used against Gram positive bacteria. It is used for serious infections and in the prevention of emerging infections in burns. Clindamycin is also effective against P. falciparum and is used as an antimalarial, either alone or in combination therapy.
|
15006 |
|
| 08.04.13 |
An inhibitor of Aurora A and B kinases
PF-
|
15015 |
|
| 08.04.13 |
A dual inhibitor of PI3K and mTOR
PF-
|
15017 |
|
| 08.04.13 |
An inhibitor of CETP activity
Torcetrapib is an inhibitor of CETP activity (IC50 = 50 nM) that raises HDL cholesterol and reduces LDL cholesterol levels by forming a nonproductive complex between CETP and HDL. Although torcetrapib produced consistent antiatherogenic effects in rabbits, clinical trials of torcetrapib were terminated early due to deleterious hypertensive effects. PDGFR, HGFR (c-
|
15028 |
|
| 04.04.13 |
A dual CDK and GSK-
Alsterpaullone is a derivative of kenpaullone (Item No. 10010239), an ATP-
|
14428 |
|
| 04.04.13 |
A cell-
(+)-
|
14007 |
|
| 04.04.13 |
An endocannabinoid
Docosaenoyl ethanolamide is a member of the family of fatty N-
|
9001745 |
|
| 04.04.13 |
An endocannabinoid
Nervonoyl ethanolamide is a member of the family of fatty N-
|
9001746 |
|
| 03.04.13 |
A natural inhibitor of GSK3 and CDK isoforms
Indirubin is a natural product originally extracted from roots and leaves of the Indigo plant (I. tinctoria) used in traditional Chinese medicine for anti-
|
14155 |
|
| 03.04.13 |
An endocannabinoid
Tricosanoyl ethanolamide is a member of the family of fatty N-
|
9001743 |
|
| 03.04.13 |
An angiotensin II receptor antagonist
Valsartan is a nonpeptide angiotensin II receptor antagonist which selectively and insurmountably inhibits the angiotensin II AT1 receptor subtype (IC50 = 2.7 nM). It has about 20,000-
|
14178 |
|
| 03.04.13 |
An endocannabinoid
γ-
|
9001747 |
|
| 02.04.13 |
A potent inhibitor of xanthine oxidoreductase
Febuxostat is an antihyperuricemic nonpurine inhibitor of both the oxidized and reduced forms of xanthine oxidase. It is 10-
|
14127 |
|
| 02.04.13 |
A multi-
Pemetrexed is pyrrotopyrimidine-
|
14269 |
|
| 01.04.13 |
A plant alkaloid used to synthesize anticancer antibiotics
Catharanthine is a precursor of the vinblastine and vincristine group of alkaloids found in the Vinca plant, C. roseus that have been used widely in chemotherapy regimens. It is biologically active in synergy with similar indole alkaloids and can be used as starting material for the synthesis of vinblastine and vincristine.
|
11695 |
|
| 01.04.13 |
A prodrug of 5-
Floxuridine is a prodrug that is rapidly catabolized in vivo to 5-
|
14154 |
|
| 01.04.13 |
An inhibitor of calpains
PD 150606 is a selective, cell-
|
13859 |
|
| 27.03.13 |
A direct activator of AMPK
A-
|
11900 |
|
| 27.03.13 |
A selective, antiviral guanosine analog
Acyclovir is a guanosine analog with antiviral activity in vitro against the herpes simplex viruses, varicella zoster virus, Epstein-
|
14160 |
|
| 27.03.13 |
Selective inhibitor of mTOR
Torin 2 is a potent and selective inhibitor of cellular mTOR activity (EC50 = 0.3 nM). It shows more than 800-
|
14185 |
|
| 26.03.13 |
A non-
Bicalutamide is a non-
|
14250 |
|
| 26.03.13 |
An indicator dye of mitochondrial transmembrane potential
JC-
|
15003 |
|
| 26.03.13 |
An endocannabinoid
Lignoceroyl ethanolamide is a member of the family of fatty N-
|
9001744 |
|
| 26.03.13 |
An endocannabinoid
Myristoyl ethanolamide is a member of the family of fatty N-
|
9001742 |
|
| 26.03.13 |
An endocannabinoid
Pentadecanoyl ethanolamide is a member of the family of fatty N-
|
9001740 |
|
| 21.03.13 |
Source:
recombinant N-
|
14136 |
|
| 20.03.13 |
A GABAA-
Flumazenil is an imidazobenzodiazepine derivative that competitively inhibits benzodiazepine binding to GABAA receptors with an IC50 value of 2 nM. Flumazenil is non-
|
14252 |
|
| 20.03.13 |
Source:
recombinant C-
|
14131 |
|
| 20.03.13 |
Source:
recombinant C-
|
14132 |
|
| 18.03.13 |
A potent aldose reductase inhibitor
EBPC is a potent, selective inhibitor of aldose reductase with an IC50 value of 47 nM in vitro. Through its regulation of glucose metabolism, EBPC has been used to improve the cytotoxic effects of the anticancer agents doxorubicin and cisplatin in HeLa cervical carcinoma cells. EBPC also inhibits prostaglandin F2α (PGF2α) and PGE2 production in human endometrial cells with an EC50 value of 10 μM.
|
14183 |
|
| 18.03.13 |
An Oct4-
OAC3 is an Oct-
|
14104 |
|
| 18.03.13 |
An internal standard for the quantification of PGD2-
Prostaglandin D2 ethanolamide (PGD2-
|
9001413 |
|
| 18.03.13 |
A selective inhibitor of RSK
SL 0101-
|
11704 |
|
| 15.03.13 |
Antigen:
human GPR12 amino acids 323-
|
14266 |
|
| 15.03.13 |
Antigen:
human GPR12 amino acids 2-
|
14267 |
|
| 15.03.13 |
An Oct4-
OAC2 is an Oct-
|
14103 |
|
| 15.03.13 |
A natural isoflavonoid
Puerarin is a natural isoflavone isolated from plants of the genus Pueraria used in traditional Chinese herbal medicine. It is biotransformed by intestinal bacteria to give the phytoestrogens daidzein (Item No. 10005166) and equol (Item No. 13184), resulting in antithrombotic, antiallergic, and other salutary effects. When given intraperitoneally, puerarin evokes diverse responses by modulating serotonin receptors. This compound also suppresses lipopolysaccharide-
|
14175 |
|
| 14.03.13 |
Antigen:
human GPR120 amino acids 364-
|
14265 |
|
| 14.03.13 |
A selective inhibitor of Ca2+/calmodulin-
KN-
|
13864 |
|
| 14.03.13 |
For the measurement of oxygen consumption rate in living cells
The oxygen consumption rate (OCR) of cells is an important indicator of normal cellular function. It is used as a parameter to study mitochondrial function as well as a marker of factors triggering the switch from healthy oxidative phosphorylation to aerobic glycolysis in cancer cells. Oxygen consumption is traditionally measured by a cumbersome oxygen electrode, a specialized piece of equipment that typically yields low sample throughput. The phosphorescent oxygen probe, MitoXpress®Xtra, developed by Luxcel Biosciences offers a novel method for analyzing oxygen consumption in whole cells. Cayman’s cell-
|
600800 |
|
| 14.03.13 |
Source:
recombinant N-
|
14073 |
|
| 13.03.13 |
Source:
recombinant N-
|
14134 |
|
| 13.03.13 |
An NMDA receptor antagonist
Memantine is an N-
|
14184 |
|
| 12.03.13 |
A neuroprotective natural product
Bilobalide is a sesquiterpene lactone which is found in extracts of G. biloba. It has been shown to protect against cerebral edema, decrease cortical infarct volume, and reduce cerebral ischemic damage. Bilobalide, at 10 μM, reduces the release of glycine and glutamate from hippocampal slices under ischemic conditions. It also activates the rat constitutive androstane receptor at 100 μM and increases the levels and activities of several cytochrome P450 isoforms in rat liver microsomes.
|
14272 |
|
| 12.03.13 |
A cell-
MS-
|
14273 |
|
| 12.03.13 |
A low-
W-
|
14271 |
|
| 11.03.13 |
An internal standard for the quantification of PGE2-
Prostaglandin E2 ethanolamide (PGE2-
|
9001412 |
|
| 08.03.13 |
An antagonist of endothelin receptors
Bosentan is an antagonist of the endothelin receptors type A (Ki = 6.5 nM) and type B (Ki = 340 nM).
|
11731 |
|
| 07.03.13 |
For the detection of sulfenic acid-
Reactive oxygen species (ROS) react with proteins, resulting in protein modification, such as protein sulfenylation through the reversible oxidation of cysteine residues. Redox-
|
600320 |
|
| 06.03.13 |
Antagonizes hematopoietic stem cell differentiation
StemRegenin 1 (SR1) is a purine derivative that antagonizes aryl hydrocarbon receptor signaling with an IC50 value of 127 nM in CD34+ cells, which results in sustained expression of CD34. Human embryonic stem cells cultured with SR1 show a 50-
|
14268 |
|
| 05.03.13 |
A naturally-
Coumestrol is a phytoestrogen that occurs naturally in soybeans, spinach, and clover. It competitively (vs. 17 β-
|
11730 |
|
| 05.03.13 |
A negative control compound for GSK-
GSK-
|
12056 |
|
| 04.03.13 |
Potent, selective Src family tyrosine kinase inhibitor
PP1 is a potent, reversible, ATP-
|
14244 |
|
| 04.03.13 |
A flavonoid with anti-
Wogonin is an O-
|
14248 |
|
| 01.03.13 |
A citrus-
Naringenin is a citrus-
|
14173 |
|
| 01.03.13 |
An irreversible inhibitor of thioredoxin-
PX 12 is a competitive, irreversible inhibitor of thioredoxin 1 (Trx1), acting by binding to Cys73 of this enzyme. As Trx1 is overexpressed in certain cancers, PX 12 is effective in suppressing the growth of cancer cells, with growth inhibition in a panel of 60 human tumors significantly correlated with expression of Trx1 mRNA. Through its effects on Trx1, PX 12 reduces hypoxia-
|
14192 |
|
| 28.02.13 |
A c-
Crizotinib is a derivative of aminopyridine that acts as a potent, orally bioavailable, ATP-
|
12087 |
|
| 28.02.13 |
A cationic peptide antibiotic
Polymyxin B (sulfate) is a mixture of at least four closely related components, polymyxin B1 to B4, with polymyxin B1 (Item No. 14074) and B2 being the two major components. Polymyxin B (sulfate) has rapid in vitro bactericidal activity against major multidrug-
|
14157 |
|
| 27.02.13 |
HDAC inhibitor with anti-
ITF 2357 inhibits class I and class II histone deacetylases (maize HDACs: HD2, HD-
|
11045 |
|
| 22.02.13 |
An internal standard for the quantification of (±)-
(±)-
|
14158 |
|