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FABP4 Protein and Assays
SIRT Recombinant Proteins
p53 Assay Kits
Methyltransferase Assay Kits
Myeloperoxidase Assay Kits
LSD1
Prostaglandin D Synthase (hematopoietic-
8-
DNA Methylation EIA Kit
New Products
Bicuculline
Olmesartan Medoxomil
Parthenolide
Docetaxel
Platycodin D
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FABP4 Protein and Assays
FABP4—a new therapeutic target for obesity and diabetes Cayman Chemical is a leading provider of high-purity, active Fatty Acid Binding Proteins. Contact our sales staff for quotations on bulk preparations of FABP4 and FABP4 assay kits for your drug discovery efforts. All FABP4 products from Cayman Chemical…SIRT Recombinant ProteinsThe sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD⁺ and the abstracted acetyl group. There are seven human sirtuins, which have been designated SIRT1-7.
p53 Assay Kits
p53 is a tumor suppressor protein which modulates the cell cycle and induces potentially cancerous cells to commit suicide. Cayman has several recently-introduced assays to help you monitor the activity of p53 in whole cells. p53 Assay Kits from Cayman ChemicalMethyltransferase Assay Kits
Enzyme-coupled assays that can continuously monitor SAM-dependent methyltransferase activity using either fluorometric or colorimetric detection reagents Methyltransferase Assay Kits from Cayman Chemical...Myeloperoxidase Assay Kits
MPO-derived oxidants contribute to tissue damage and the initiation and propagation of acute and chronic vascular inflammatory diseases. Circulating levels of MPO predict risks for major adverse cardiac events. Cayman’s MPO assay kits provide convenient fluorescent-based methods for detecting either chlorination or peroxidation activity of MPO and for screening inhibitors to these activities. Myeloperoxidase Assay Kits from Cayman Chemical...LSD1
Lysine-specific demethylase 1 (LSD1) is a histone demethylase whose actions on specific lysine residues on H3 alter gene transcription on chromosomal DNA. The LSD1 protein includes an amino-terminal SWIRM domain, an unusual coiled-coil tower structure, and a FAD-containing amine oxidase domain.
A convenient fluorescence polarization-
Cayman’s H-
A competitive EIA for quantification of 8-
Cayman’s 8-
A competitive EIA for the quantification of 5-
Cayman’s DNA Methylation EIA is a competitive assay that can be used for the quantification of 5-
A GABAA receptor antagonist
Bicuculline is a competitive GABAA receptor antagonist that can act as an allosteric inhibitor at GABAA receptors. At 100 μM, it blocks spontaneously opening chloride channels in the outside-
Prodrug for a selective angiotensin II receptor antagonist
Olmesartan Medoxomil is a prodrug that is metabolized in vivo to RNH-
A natural inhibitor of NOD2 and NF-
Parthenolide is a sesquiterpene lactone from the plant feverfew (T. parthenium). It inhibits the growth of the promastigote form of L. amazonensis (IC50 = 3.6 μg/ml). Parthenolide also induces apoptosis in cancer cells, at least in part by …
An analog of taxol with antitumor properties
Docetaxel is a semisynthetic analog of taxol that inhibits microtubule disassembly (IC50 = 0.2 μM) and inhibits cell replication (IC50 = 0.13 μM). It has proven more effective than taxol in preventing the proliferation of cancer cells. Docetaxel has applications in breast cancer and …
A saponin isolated from a Chinese medicinal herb
Platycodin D is a saponin isolated from the root of P. grandiflorum. Root preparations have been used extensively in Chinese herbal medicine for many applications, particularly for upper respiratory disorders and inflammation. The cellular and physiological actions of purified platycodin …
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